Article
Sub-inhibitory concentrations of oxacillin modify the expression of agr locus in Staphylococcus aureus clinical strains belonging to different clonal complexes.
BMC infectious diseases - 16 Apr 2018
Viedma Esther, Pérez-Montarelo Dafne, Villa Jennifer, Muñoz-Gallego Irene, Larrosa Nieves, Fernández-Hidalgo Nuria, Gavaldà Joan, Almirante Benito, Chaves Fernando
Abstract excerpt
BACKGROUND: The ability of Staphylococcus aureus to invade tissues and cause an infectious disease is the result of a multi-factorial process supported by the huge number of virulence factors inherent to this microorganism tightly regulated by the accessory gene regulator (agr). During antimicrobial therapy bacteria may be exposed to sub-inhibitory concentrations (subMICs) of antibiotics that may trigger...
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