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Article

walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Aug 2011

Shoji Mitsutaka, Cui Longzhu, Iizuka Risa, Komoto Akira, Neoh Hui-min, Watanabe Yukiko, Hishinuma Tomomi, Hiramatsu Keiichi

Abstract excerpt

Vancomycin-intermediate Staphylococcus aureus (VISA) is generated from vancomycin-susceptible Staphylococcus aureus by multiple spontaneous mutations. We previously reported that sequential acquisition of mutations in the two-component regulatory systems vraSR and graRS was responsible for the VISA phenotype of strain Mu50. Here we report on the identification of a novel set of regulator mutations, a deletion...

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Identifiers

PMID: 21628539
DOI: 10.1128/AAC.01563-10
PMCID: PMC3147622

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walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.PMID 21628539Read ↗

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