Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations.

doi:10.1038/s41408-023-00975-8

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Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations.

Blood cancer journal - 23 Jan 2024

Tien Feng-Ming, Yao Chi-Yuan, Tsai Xavier Cheng-Hong, Lo Min-Yen, Chen Chien-Yuan, Lee Wan-Hsuan, Lin Chien-Chin, Kuo Yuan-Yeh, Peng Yen-Ling, Tseng Mei-Hsuan, Wu Yu-Sin, Liu Ming-Chih, Lin Liang-In, Chuang Ming-Kai, Ko Bor-Sheng, Yao Ming, Tang Jih-Luh, Chou Wen-Chien, Hou Hsin-An, Tien Hwei-Fang

Abstract excerpt

Acute myeloid leukemia (AML) with CEBPA bZIP in-frame mutations (CEBPAbZIP-inf) is classified within the favorable-risk group by the 2022 European LeukemiaNet (ELN-2022). However, heterogeneous clinical outcomes are still observed in these patients. In this study, we aimed to investigate the mutation profiles and transcriptomic patterns associated with poor outcomes in patients with CEBPAbZIP-inf. One hundred and...

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PMID: 38253683
DOI: 10.1038/s41408-023-00975-8
PMCID: PMC10803338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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