CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome.

doi:10.1182/blood.2020009680

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CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome.

Blood - 6 Jan 2022

Taube Franziska, Georgi Julia Annabell, Kramer Michael, Stasik Sebastian, Middeke Jan Moritz, Röllig Christoph, Krug Utz, Krämer Alwin, Scholl Sebastian, Hochhaus Andreas, Brümmendorf Tim H, Naumann Ralph, Petzold Andreas, Mulet-Lazaro Roger, Valk Peter J M, Steffen Björn, Einsele Hermann, Schaich Markus, Burchert Andreas, Neubauer Andreas, Schäfer-Eckart Kerstin, Schliemann Christoph, Krause Stefan W, Hänel Mathias, Noppeney Richard, Kaiser Ulrich, Baldus Claudia D, Kaufmann Martin, Herold Sylvia, Stölzel Friedrich, Sockel Katja, von Bonin Malte, Müller-Tidow Carsten, Platzbecker Uwe, Berdel Wolfgang E, Serve Hubert, Ehninger Gerhard, Bornhäuser Martin, Schetelig Johannes, Thiede Christian

Abstract excerpt

Biallelic mutations of the CEBPA gene (CEBPAbi) define a distinct entity associated with favorable prognosis; however, the role of monoallelic mutations (CEBPAsm) is poorly understood. We retrospectively analyzed 4708 adults with acute myeloid leukemia (AML) who had been recruited into the Study Alliance Leukemia trials, to investigate the prognostic impact of CEBPAsm. CEBPA mutations were identified in 240...

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PMID: 34320176
DOI: 10.1182/blood.2020009680

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