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Article

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses.

Leukemia - 1 Apr 2021

Adnan Awad Shady, Dufva Olli, Ianevski Aleksandr, Ghimire Bishwa, Koski Jan, Maliniemi Pilvi, Thomson Daniel, Schreiber Andreas, Heckman Caroline A, Koskenvesa Perttu, Korhonen Matti, Porkka Kimmo, Branford Susan, Aittokallio Tero, Kankainen Matti, Mustjoki Satu

Abstract excerpt

Blast-phase chronic myeloid leukemia (BP-CML) is associated with additional chromosomal aberrations, RUNX1 mutations being one of the most common. Tyrosine kinase inhibitor therapy has only limited efficacy in BP-CML, and characterization of more defined molecular subtypes is warranted in order to design better treatment modalities for this poor prognosis patient group. Using whole-exome and RNA sequencing we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32782381
DOI: 10.1038/s41375-020-01011-5
PMCID: PMC8024199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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