Article
Integrative Genomic and Immune Profiling to Identify and Characterize High-Risk Subgroups in Acute Myeloid Leukemia: Development of a 20-Gene Predictive Signature and Its Clinical Implications.
Omics : a journal of integrative biology - 1 Sept 2025
Karagoz Kubra, Roukens M Guy, Comijn Lizzy, Celik Asuman, Brady Lauren K, Higgs Brandon W, Si Han
Abstract excerpt
Acute myeloid leukemia (AML) is a heterogeneous malignancy with diverse genetic mutations and oncogenic pathways influencing treatment response. Despite therapeutic advances, relapse and resistance remain persistent issues. This study integrates genomic and transcriptomic profiling to identify biomarkers of high-risk AML, informing personalized medicine strategies. Nonnegative matrix factorization was applied to...
Topics
- Humans
- Leukemia, Myeloid, Acute
- Nucleophosmin
- Gene Expression Profiling
- Genomics
- Tumor Microenvironment
- Biomarkers, Tumor
- Mutation
- Transcriptome
- Female
- Male
- Prognosis