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Article

Single Ion Pair Is Essential for Stabilizing SHP2's Open Conformation.

Biochemistry - 6 Feb 2024

Kim Sean H, Bulos Maya L, Adams Jennifer A, Yun B Koun, Bishop Anthony C

Abstract excerpt

Src-homology-2-domain-containing PTP-2 (SHP2) is a widely expressed signaling enzyme whose misregulation is associated with multiple human pathologies. SHP2's enzymatic activity is controlled by a conformational equilibrium between its autoinhibited ("closed") state and its activated ("open") state. Although SHP2's closed state has been extensively characterized, the putative structure of its open form has only...

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Identifiers

PMID: 38251939
DOI: 10.1021/acs.biochem.3c00609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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