Article

Immunogenomic Biomarkers for Early Cancer Detection in Lynch Syndrome

2022-07-26

Abstract excerpt

Lynch syndrome (LS) is an inherited disorder in which affected individuals have a significantly higher-than-average risk of developing colorectal and non-colorectal cancers, often before the age of 50 years. In LS, mutations in DNA repair genes lead to a dysfunctional post-replication repair system. As a result, the unrepaired errors in coding regions of the genome produce novel proteins, called neoantigens. Neoan...

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Literature Corpus work: 974ab3f9-40aa-5264-ae22-38d67b83d9ab
DOI: 10.20944/preprints202207.0408.v1

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