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Article

PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde.

Journal of controlled release : official journal of the Controlled Release Society - 1 Feb 2024

Gu Ziqi, Zhao Hang, Song Yilan, Kou Yiduo, Yang Wanting, Li Ye, Li Xiang, Ding Ling, Sun Zihui, Lin Jing, Wang Qi, Li Xi, Yang Xu, Huang Xuerong, Yang Chuang, Tong Zhiqian

Abstract excerpt

Alzheimer's disease (AD), which is a prevailing type of dementia, presents a significant global health concern. The current therapies do not meet clinical expectations. Amyloid-beta (Aβ) has been found to induce endogenous formaldehyde (FA) accumulation by inactivating FA dehydrogenase (FDH); in turn, excessive FA triggers Aβ aggregation that eventually leads to AD onset. Hence, scavenging FA by astaxanthin (ATX,...

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Identifiers

PMID: 38242211
DOI: 10.1016/j.jconrel.2024.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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