Article
Aβ seeds resist inactivation by formaldehyde.
Acta neuropathologica - 1 Oct 2014
Fritschi Sarah K, Cintron Amarallys, Ye Lan, Mahler Jasmin, Bühler Anika, Baumann Frank, Neumann Manuela, Nilsson K Peter R, Hammarström Per, Walker Lary C, Jucker Mathias
Abstract excerpt
Cerebral β-amyloidosis can be exogenously induced by the intracerebral injection of brain extracts containing aggregated β-amyloid (Aβ) into young, pre-depositing Aβ precursor protein- (APP) transgenic mice. Previous work has shown that the induction involves a prion-like seeding mechanism in which the seeding agent is aggregated Aβ itself. Here we report that the β-amyloid-inducing activity of Alzheimer's...
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