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Article

Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes.

Molecular psychiatry - 1 Oct 2021

Fei Xuechao, Zhang Yun, Mei Yufei, Yue Xiangpei, Jiang Wenjing, Ai Li, Yu Yan, Luo Hongjun, Li Hui, Luo Wenhong, Yang Xu, Lyv Jihui, He Rongqiao, Song Weihong, Tong Zhiqian

Abstract excerpt

Dysregulation of formaldehyde (FA) has been implicated in the development of Alzheimer's Disease (AD). Elevated FA levels in Alzheimer's patients and animal models are associated with impaired cognitive functions. However, the exact role of FA in AD remains unknown. We now identified that oxidative demethylation at serine8/26 of amyloid-beta protein (Aβ) induced FA generation and FA cross-linked with the lysine28...

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Identifiers

PMID: 33328587
DOI: 10.1038/s41380-020-00929-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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