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Article

The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders.

Blood cancer journal - 18 Jan 2024

Semenzato Gianpietro, Calabretto Giulia, Teramo Antonella, Gasparini Vanessa Rebecca, Rampazzo Elisa, Barilà Gregorio, Zambello Renato

Abstract excerpt

Type T Large Granular Lymphocyte Leukemia (T-LGLL) is a chronic disorder characterized by the abnormal proliferation of clonal cytotoxic T cells. The intriguing association of T-LGLL with autoimmune and inflammatory diseases, the most prominent example being rheumatoid arthritis, raises questions about the underlying pathophysiologic relationships between these disorders which share several biological and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunodeficiency and Autoimmune Disorders

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Share to Leukemia, Large Granular Lymphocytic

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Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 38238319
DOI: 10.1038/s41408-024-00977-0
PMCID: PMC10796758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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