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Article

Discovery of Dysimmunity in Large Granular Lymphocytic Leukemia (LGLL) using Bioinformatic Analysis.

Clinical laboratory - 1 Apr 2021

Lu Guang, Du Jun, Mou Weiwei, Hu Jing, Han Xin-le

Abstract excerpt

BACKGROUND: Large granular lymphocytic leukemia (LGLL) is a chronic lymphoproliferative disorder characterized by the clonal proliferation of large granular lymphocytes (LGL), classified as T and NK subtypes. Although JAK/STAT pathway gene mutation, such as STAT3/STAT5B, is the dominant driver in the proliferation of LGLL, immune abnormality remains an unsolved puzzle in the pathogenesis. METHODS: By means of...

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Identifiers

PMID: 33865255
DOI: 10.7754/Clin.Lab.2020.200819

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