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Article

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

11 Nov 2019

Abstract excerpt

The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide crucial support to the retina. Disease affecting either of these supportive tissues can lead to irreversible blindness in the setting of age-related macular degeneration. In this study, single-cell RNA sequencing was performed on macular and peripheral regions of RPE-choroid from 7 human donor eyes in 2 independent...

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PMID: 31712411
DOI: 10.1073/pnas.1914143116

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