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Article

Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.

Microvascular research - 1 Sept 2020

Voigt Andrew P, Whitmore S Scott, Mulfaul Kelly, Chirco Kathleen R, Giacalone Joseph C, Flamme-Wiese Miles J, Stockman Adam, Stone Edwin M, Tucker Budd A, Scheetz Todd E, Mullins Robert F

Abstract excerpt

The human choroidal vasculature is subject to age-related structural and gene expression changes implicated in age-related macular degeneration (AMD). In this study, we performed both bulk and single-cell RNA sequencing on infant (n = 4 for bulk experiments, n = 2 for single-cell experiments) and adult (n = 13 for bulk experiments, n = 6 for single-cell experiments) human donors to characterize how choroidal gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32531351
DOI: 10.1016/j.mvr.2020.104031
PMCID: PMC7396301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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