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Article

Split G-quadruplex based PfAgo sensing platform for nucleotide mutation discrimination and human genotyping.

The Analyst - 29 Jan 2024

Zhang Yan, Gong Bin, Lin Yanan, Zhu Yuedong, Su Gaoxing, Yu Yanyan

Abstract excerpt

A PfAgo-G4 sensing platform exploiting G4 as a signal reporter was proposed, validated, and optimized. By introducing two mismatches at the Link strand, a universal nucleotide design rule was established for accurate single nucleotide polymorphism discrimination with PfAgo-G4. The FUT2 gene was then successfully and accurately genotyped using human buccal swab samples.

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PMID: 38230655
DOI: 10.1039/d3an02090h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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