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Article

A graphene-based platform for single nucleotide polymorphism (SNP) genotyping.

Biosensors & bioelectronics - 15 Jun 2011

Liu Meng, Zhao Huimin, Chen Shuo, Yu Hongtao, Zhang Yaobin, Quan Xie

Abstract excerpt

A facile, rapid, stable and sensitive approach for fluorescent detection of single nucleotide polymorphism (SNP) is designed based on DNA ligase reaction and π-stacking between the graphene and the nucleotide bases. In the presence of perfectly matched DNA, DNA ligase can catalyze the linkage of fluorescein amidite-labeled single-stranded DNA (ssDNA) and a phosphorylated ssDNA, and thus the formation of a stable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21514138
DOI: 10.1016/j.bios.2011.03.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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