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Article

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox.

Aging cell - 1 Sept 2020

Yang Liang, Lin Xiaobing, Tang Haite, Fan Yuting, Zeng Sheng, Jia Lei, Li Yukun, Shi Yanan, He Shujing, Wang Hao, Hu Zhijuan, Gong Xiao, Liang Xiaoyan, Yang Yi, Liu Xingguo

Abstract excerpt

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate fertility remains unknown. Here, we analyzed oocyte quality of young (≤30 years old) and elder (≥38 years old) female patients and show the elder group had lower blastocyst formation rate and more mtDNA point mutations in oocytes. To test the...

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Identifiers

PMID: 32744417
DOI: 10.1111/acel.13206
PMCID: PMC7511885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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