Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner

28 Jul 2021

Abstract excerpt

Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue (WAT) of 8-week-old male and female mouse offspring. Methods: C57BL/6J female mice were provided with a control (Con) or obesogenic diet (Ob) to induce pre-conception obesity. Half the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Birth, Development, and Health
Share to Gestational Diabetes Research and Management

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34360870
DOI: 10.3390/ijms22158104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific MannerPMID 34360870Read ↗

The effect of metformin intervention on the programming of cardiometabolic health in offspring of obese pregnancySemantic proximity Read ↗

Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.Semantic proximity Read ↗

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice OffspringSemantic proximity Read ↗

Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gainSemantic proximity Read ↗

Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific mannerSemantic proximity Read ↗

Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent manners.Semantic proximity Read ↗

Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice.Semantic proximity Read ↗

Altered metabolic health during pregnancy in mice with lean polycystic ovary syndrome-like traits from high prenatal AMHSemantic proximity Read ↗

Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice.Semantic proximity Read ↗

Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspringSemantic proximity Read ↗

Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female miceSemantic proximity Read ↗

Maternal western diet primes non‐alcoholic fatty liver disease in adult mouse offspringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.