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Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice

23 May 2023

Abstract excerpt

Sex differences in aging and longevity have been widely observed, with females consistently outliving males across human populations. However, the mechanisms driving these disparities remain poorly understood. In this study, we explored the influence of post-pubertal testicular effects on sex differences in aging by prepubertally castrating genetically heterogeneous (UM-HET3) mice, a unique mouse model that...

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PMID: 37221997
DOI: 10.1111/acel.13891

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