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Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression

22 Dec 2023

Abstract excerpt

Meiosis is a key step during germ cell differentiation, accompanied by the activation of thousands of genes through germline-specific chromatin reorganization. The chromatin remodeling mechanisms underpinning early meiotic stages remain poorly understood. Here we focus on the function of one of the major autism genes, CHD8, in spermatogenesis, based on the epidemiological association between autism and low...

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PMID: 38224953
DOI: 10.1093/nar/gkad1256

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