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Article

Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

29 Sept 2021

Abstract excerpt

Meiotic arrest is a common cause of human male infertility, but the causes of this arrest are poorly understood. Transactive response DNA-binding protein of 43 kDa (TDP-43) is highly expressed in spermatocytes in the preleptotene and pachytene stages of meiosis. TDP-43 is linked to several human neurodegenerative disorders wherein its nuclear clearance accompanied by cytoplasmic aggregates underlies...

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PMID: 34599968
DOI: 10.1016/j.jbc.2021.101231

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