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Article

Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.

Genetics - 6 Mar 2024

AbuAlia Khawla F N, Damm Elena, Ullrich Kristian K, Mukaj Amisa, Parvanov Emil, Forejt Jiri, Odenthal-Hesse Linda

Abstract excerpt

PRDM9-mediated reproductive isolation was first described in the progeny of Mus musculus musculus (MUS) PWD/Ph and Mus musculus domesticus (DOM) C57BL/6J inbred strains. These male F1 hybrids fail to complete chromosome synapsis and arrest meiosis at prophase I, due to incompatibilities between the Prdm9 gene and hybrid sterility locus Hstx2. We identified 14 alleles of Prdm9 in exon 12, encoding the DNA-binding...

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PMID: 38217871
DOI: 10.1093/genetics/iyae004
PMCID: PMC10917509

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