Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.

doi:10.1038/s41437-026-00834-9

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Article

Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.

Heredity - 1 May 2026

Klusáčková Pavla, Woźniewska Agata, Dufková Petra, Dumont Beth L, Wójcik Jan M, Piálek Jaroslav

Abstract excerpt

Hybrid sterility is a critical postzygotic barrier that limits gene flow during speciation, yet the genetic architecture underlying evolution of such barriers in the early stages of speciation remains poorly characterized. In house mice, F1 male sterility observed in crosses between Mus musculus musculus and M. m. domesticus has been attributed to incompatibilities between heterozygous autosomal Prdm9, which...

Topics

Animals
Male
Infertility, Male
Mice
Quantitative Trait Loci
Histone-Lysine N-Methyltransferase
Hybridization, Genetic
Evolution, Molecular
Crosses, Genetic
Female
Chromosome Mapping
Genes, X-Linked
Phenotype
Models, Genetic
MicroRNAs

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Identifiers

PMID: 41820541
DOI: 10.1038/s41437-026-00834-9
PMCID: PMC13219761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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