Article
Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.
PLoS genetics - 1 Jan 2012
Flachs Petr, Mihola Ondřej, Simeček Petr, Gregorová Soňa, Schimenti John C, Matsui Yasuhisa, Baudat Frédéric, de Massy Bernard, Piálek Jaroslav, Forejt Jiří, Trachtulec Zdenek
Abstract excerpt
The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene level in mammals. The Hybrid sterility 1 gene (Hst1) participates in the arrest of meiosis in F(1) males of certain strains from two Mus musculus subspecies, e.g., PWD...
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