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Article

A Mutation of the Prdm9 Mouse Hybrid Sterility Gene Carried by a Transgene.

Folia biologica - 1 Jan 2017

Mihola O, Trachtulec Z

Abstract excerpt

PRDM9 is a protein with histone-3-methyltransferase activity, which specifies the sites of meiotic recombination in mammals. Deficiency of the Prdm9 gene in the laboratory mouse results in complete arrest of the meiotic prophase of both sexes. Moreover, the combination of certain PRDM9 alleles from different mouse subspecies causes hybrid sterility, e.g., the male-specific meiotic arrest found in the (PWD/Ph ×...

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Source

Identifiers

PMID: 28374672
DOI: 10.14712/fb2017063010027

Genes

PRDM9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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A Mutation of the Prdm9 Mouse Hybrid Sterility Gene Carried by a Transgene.PMID 28374672Read ↗

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.Semantic proximity Read ↗

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Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.Semantic proximity Read ↗

Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguardSemantic proximity Read ↗

Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.Semantic proximity Read ↗

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.Semantic proximity Read ↗

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Differential effects of two catalytic mutations on full-length PRDM9 and its isolated PR/SET domain reveal a case of pseudomodularity.Semantic proximity Read ↗

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