Article
Causal effects of osteoporosis on structural changes in specific brain regions: a Mendelian randomization study.
Cerebral cortex (New York, N.Y. : 1991) - 31 Jan 2024
Nie Xinlin, Zhang Qiong, Wang Yixuan, Liu Zhaoliang, Xie Dongheng, Song Qingxu, Yang Chen, Yu Tiecheng, Sun Yang
Abstract excerpt
Observational studies have reported that osteoporosis is associated with cortical changes in the brain. However, the inherent limitations of observational studies pose challenges in eliminating confounding factors and establishing causal relationships. And previous observational studies have not reported changes in specific brain regions. By employing Mendelian randomization, we have been able to infer a causal...
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