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Article

Severe traumatic brain injury and risk for osteoporosis: a Mendelian randomization study.

BMC medical genomics - 31 Mar 2025

Wang Guoqiang, Wang Jiachen, Yang Dinglong, Liu Lin, Xu Peng

Abstract excerpt

BACKGROUND: The influence of nervous system activity on bone remodeling has been widely reported. Patients with traumatic brain injury (TBI) exhibit a high incidence of osteoporosis (OP). Nevertheless, the relationship between severe TBI (sTBI) and OP remains unclear. We performed Mendelian randomization (MR) analysis to assess the potential causal relationship between sTBI and OP. METHODS: Data on exposure and...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Osteoporosis
Brain Injuries, Traumatic
Polymorphism, Single Nucleotide
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Male

Female

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40165268
DOI: 10.1186/s12920-025-02127-2
PMCID: PMC11959788

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