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Generation of hypoimmunogenic universal iPS cells through HLA-type gene knockout

14 Mar 2025

Abstract excerpt

Hypoimmunogenic universal induced pluripotent stemn (iPS) cells were generated through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B and HLA-DR alpha (DRA), using the CRISPR-Cas9 system. This approach aimed to minimize immune recognition and enhance the potential of iPS cells for allogeneic therapy. Heterozygous iPS cells were used for guide RNA design and validation to...

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PMID: 40087529
DOI: 10.1038/s12276-025-01422-3

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