Article
Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice.
Cellular and molecular life sciences : CMLS - 12 Jan 2024
Forte Nicola, Nicois Alessandro, Marfella Brenda, Mavaro Isabella, D'Angelo Livia, Piscitelli Fabiana, Scandurra Anna, De Girolamo Paolo, Baldelli Pietro, Benfenati Fabio, Di Marzo Vincenzo, Cristino Luigia
Abstract excerpt
The mechanism underlying the transition from the pre-symptomatic to the symptomatic state is a crucial aspect of epileptogenesis. SYN2 is a member of a multigene family of synaptic vesicle phosphoproteins playing a fundamental role in controlling neurotransmitter release. Human SYN2 gene mutations are associated with epilepsy and autism spectrum disorder. Mice knocked out for synapsin II (SynII KO) are prone to...
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