Article
Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/- mice.
Pharmacological reports : PR - 1 Aug 2018
Kopanitsa Maksym V, Gou Gemma, Afinowi Nurudeen O, Bayés Àlex, Grant Seth G N, Komiyama Noboru H
Abstract excerpt
BACKGROUND: Synaptic Ras-GTPase-activating protein 1 (SYNGAP1) is an abundant brain-specific protein localized at the postsynaptic density of mammalian excitatory synapses. SYNGAP1 functions as a crucial regulator of downstream intracellular signaling triggered by N-methyl-d-aspartate receptor activation. One of the most important signaling pathways regulated by SYNGAP1 is the Ras-Raf-MEK-ERK pathway. SYNGAP1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.