Article
The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype.
Cerebral cortex (New York, N.Y. : 1991) - 1 Oct 2017
Michetti Caterina, Caruso Angela, Pagani Marco, Sabbioni Mara, Medrihan Lucian, David Gergely, Galbusera Alberto, Morini Monica, Gozzi Alessandro, Benfenati Fabio, Scattoni Maria Luisa
Abstract excerpt
Autism spectrum disorders (ASD) and epilepsy are neurodevelopmental conditions that appear with high rate of co-occurrence, suggesting the possibility of a common genetic basis. Mutations in Synapsin (SYN) genes, particularly SYN1 and SYN2, have been recently associated with ASD and epilepsy in humans. Accordingly, mice lacking Syn1 or Syn2, but not Syn3, experience epileptic seizures and display autistic-like...
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