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Article

Diversity and diversification of light chains in myeloma: the specter of amyloidogenesis by proxy.

Contributions to nephrology - 1 Jan 2007

Gu Minyi, Wilton Rosemary, Stevens Fred J

Abstract excerpt

BACKGROUND/AIMS: Primary amyloidosis and the cancer, multiple myeloma, are characterized by the overproduction of free antibody light chains. Approximately 10% of myeloma patients develop amyloidosis; primary amyloidosis may be thought of as the pathological analog of monoclonal gammopathy of undetermined significance. The kidney is a common site of accumulation of amyloid fibrils and is also the target of other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17075229
DOI: 10.1159/000096766

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