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Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population

10 Jan 2024

Abstract excerpt

Importance: The genetic basis of coronary heart disease (CHD) has expanded from a germline to somatic genome, including clonal hematopoiesis of indeterminate potential (CHIP). How CHIP confers CHD risk in East Asian individuals, especially those with small clones (variant allele fraction [VAF] 0.5%-2%) and different genetic backgrounds, was completely unknown. Objective: To investigate the CHIP profile in a...

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PMID: 38198131
DOI: 10.1001/jamacardio.2023.5095

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