Article
Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.
Communications biology - 5 Jan 2024
Lawir Divine-Fondzenyuy, Soza-Ried Cristian, Iwanami Norimasa, Siamishi Iliana, Bylund Göran O, O Meara Connor, Sikora Katarzyna, Kanzler Benoît, Johansson Erik, Schorpp Michael, Cauchy Pierre, Boehm Thomas
Abstract excerpt
The stability of cellular phenotypes in developing organisms depends on error-free transmission of epigenetic and genetic information during mitosis. Methylation of cytosine residues in genomic DNA is a key epigenetic mark that modulates gene expression and prevents genome instability. Here, we report on a genetic test of the relationship between DNA replication and methylation in the context of the developing...
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