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Article

Transgenerational inheritance of impaired larval T cell development in zebrafish.

Nature communications - 9 Sept 2020

Iwanami Norimasa, Lawir Divine-Fondzenyuy, Sikora Katarzyna, O Meara Connor, Takeshita Kohei, Schorpp Michael, Boehm Thomas

Abstract excerpt

Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the stage for transmission into future generations. Here, we describe a viable hypomorphic allele of dnmt1 in zebrafish that causes widespread demethylation of CpG dinucleotides in sperm and somatic tissues. We find that homozygous mutants are essentially normal,...

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Identifiers

PMID: 32908148
DOI: 10.1038/s41467-020-18289-9
PMCID: PMC7481223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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