Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer.

doi:10.1016/bs.acc.2017.10.002

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Article

Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer.

Advances in clinical chemistry - 1 Jan 2000

Ishige Takayuki, Itoga Sakae, Matsushita Kazuyuki

Abstract excerpt

The molecular diagnosis of the cancer mutational status is essential for modern clinical laboratory medicine. Mutations in EGFR, KRAS, BRAF, and PIK3CA genes are widely analyzed in solid tumors such as lung cancer, colorectal cancer, breast cancer, and melanoma. The allele-specific polymerase chain reaction, high-resolution melting, and Sanger sequencing are used for detecting and identifying gene mutations in...

Topics

DNA Mutational Analysis
Humans
Mutation
Neoplasms
Oligonucleotides
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 29304903
DOI: 10.1016/bs.acc.2017.10.002

Genes

BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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