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Restriction Endonuclease-Assisted Recombinase Polymerase Amplification: Application towards the Detection of ctDNA.

Talanta - 15 May 2026

Song Zhirui, Xiao Yugang, Zhang Hongbo, Wu Xiaoke, Tan Yan, Zhu Qubo

Abstract excerpt

Circulating tumor DNA (ctDNA) represents an invaluable liquid biomarker with significant applications in early cancer screening, therapeutic efficacy evaluation, and recurrence monitoring. However, ctDNA detection faces some challenges: low abundance in plasma cell-free DNA (cfDNA), difficulty in distinguishing mutant from wild-type signals using conventional methods, and loss of short fragments due to length...

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PMID: 41581303
DOI: 10.1016/j.talanta.2026.129445

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