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Rapid detection of EGFR mutation in CTCs based on a double spiral microfluidic chip and the real-time RPA method.

Analytical and bioanalytical chemistry - 1 Jul 2023

Li Wen-Man, Ren Xiao-Dong, Jiang Yu-Zhu, Su Ning, Li Bo-Wen, Sun Xian-Ge, Li Ruo-Xu, Lu Wei-Ping, Deng Shao-Li, Li Jin, Li Meng-Xia, Huang Qing

Abstract excerpt

Circulating tumor cells (CTCs) are cells shed from primary or metastatic tumors and spread into the peripheral bloodstream. Mutation detection in CTCs can reveal vital genetic information about the tumors and can be used for "liquid biopsy" to indicate cancer treatment and targeted medication. However, current methods to measure the mutations in CTCs are based on PCR or DNA sequencing which are cumbersome and...

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PMID: 37254002
DOI: 10.1007/s00216-023-04743-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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