Article

Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations

2020-06-21

Abstract excerpt

Acquired genetic mutations can confer resistance to arsenic trioxide (ATO) in the treatment of acute promyelocytic leukemia (APL). However, such resistance-conferring mutations are rare and do not explain the majority of disease recurrence seen in the clinic. We have generated a stable ATO resistant promyelocytic cell from a ATO sensitive NB4 cell line. We also noted that another ATRA resistant cell line (UF1) was...

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Literature Corpus work: f73cf73b-ecdb-5240-92f2-9e40d6a3eb47
DOI: 10.1101/2020.06.21.154633

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