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Article

Arsenic trioxide and all-trans retinoic acid suppress the expression of FLT3-ITD.

Leukemia & lymphoma - 1 Nov 2020

Liang Cong, Peng Chun-Jin, Wang Li-Na, Li Yu, Zheng Li-Min, Fan Zhong, Huang Dan-Ping, Tang Wen-Yan, Zhang Xiao-Li, Huang Li-Bin, Tang Yan-Lai, Luo Xue-Qun

Abstract excerpt

The prognosis of patients with acute myeloid leukemia (AML) caused by the FLT3-ITD mutation is poor. Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) can down-regulate FLT3-ITD level and selectively kill leukemia cells carrying the FLT3-ITD mutation. However, the mechanisms of action of these two compounds are unknown. Here, we found that ATO could bind FLT3-ITD at Lys91 and Asp225, whereas ATRA could...

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Identifiers

PMID: 32536235
DOI: 10.1080/10428194.2020.1775212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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