LYmphoid NeXt-Generation Sequencing (LYNX) Panel: A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies.

doi:10.1016/j.jmoldx.2021.05.007

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Article

LYmphoid NeXt-Generation Sequencing (LYNX) Panel: A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies.

The Journal of molecular diagnostics : JMD - 1 Aug 2021

Navrkalova Veronika, Plevova Karla, Hynst Jakub, Pal Karol, Mareckova Andrea, Reigl Tomas, Jelinkova Hana, Vrzalova Zuzana, Stranska Kamila, Pavlova Sarka, Panovska Anna, Janikova Andrea, Doubek Michael, Kotaskova Jana, Pospisilova Sarka

Abstract excerpt

B-cell neoplasms represent a clinically heterogeneous group of hematologic malignancies with considerably diverse genomic architecture recently endorsed by next-generation sequencing (NGS) studies. Because multiple genetic defects have a potential or confirmed clinical impact, a tendency toward more comprehensive testing of diagnostic, prognostic, and predictive markers is desired. This study introduces the...

Topics

Biomarkers, Tumor
Chromosome Aberrations
Computational Biology
DNA Copy Number Variations
Genetic Predisposition to Disease
Genetic Variation
Genomics
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

INDEL Mutation

Leukemia, Lymphoid

Lymphoma

Molecular Diagnostic Techniques

Prognosis

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 34082072
DOI: 10.1016/j.jmoldx.2021.05.007

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