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Article

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications

2025-03-19

Abstract excerpt

The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a process essential for the methylation of homocysteine to methionine. Polymorphisms in the MTHFR gene can reduce enzyme activity, disrupting the folate cycle and leading to hyperhomocysteinemia. The two most common polymorphisms associated with this gene are 667C&...

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Literature Corpus work
106ee667-bfda-5f75-91d1-8ed657f7aa5f
DOI
10.20944/preprints202503.1383.v1
Open publication

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MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical ImplicationsDOI 10.20944/preprints202503.1383.v1
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