Article
The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Feb 2012
La Merrill Michele, Torres-Sánchez Luisa, Ruiz-Ramos Rubén, López-Carrillo Lizbeth, Cebrián Mariano E, Chen Jia
Abstract excerpt
OBJECTIVE: Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women. METHODS: A semi-quantitative dietary questionnaire was administered to 195 women during their first trimester in Morelos, Mexico. Two functional polymorphisms of the key folate-metabolizing gene, i.e. MTHFR 677 C>T and 1298...
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