Article
Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.
The American journal of clinical nutrition - 1 Nov 2009
Ericson Ulrika C, Ivarsson Malin I L, Sonestedt Emily, Gullberg Bo, Carlson Joyce, Olsson Håkan, Wirfält Elisabet
Abstract excerpt
BACKGROUND: Folate is involved in DNA synthesis and methylation and may thereby influence carcinogenesis. OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C-->T (rs1801133) and 1298A-->C (rs1801131)]. We also explored whether P-folate was associated with risk of postmenopausal breast cancer...
Topics
- Aged
- Breast Neoplasms
- Case-Control Studies
- DNA Primers
- DNA Replication
- Female