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Article

The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2023

van Otterdijk Sanne D, Klett Hagen, Boerries Melanie, Michels Karin B

Abstract excerpt

Folate plays an important role in the modulation of one-carbon metabolism and DNA methylation through a complex biosynthesis pathway. Folate deficiency during pregnancy has been associated with an increased risk for birth defects. This study investigates the extent to which the availability of folate and S-Adenosylmethionine (SAM) affects placental DNA methylation. We hypothesized that maintaining sufficient...

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Source

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Identifiers

PMID: 36520012
DOI: 10.1096/fj.202200476RR
PMCID: PMC13281835

Genes

MTHFR

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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