Article
[The role of the encephalomyocarditis virus type 1 proteins L and 2A in the inhibition of the synthesis of cellular proteins and the accumulation of viral proteins during infection].
Voprosy virusologii - 7 Nov 2023
Ivin Y Y, Butusova A A, Gladneva E E, Kolomijtseva G Y, Khapchaev Y K, Ishmukhametov A A
Abstract excerpt
INTRODUCTION: Infection of cells with encephalomyocarditis virus type 1 (EMCV-1, Cardiovirus A:Picornaviridae) is accompanied by suppression of cellular protein synthesis. The main role in the inhibition of cellular translation is assigned to the L and 2A «security» proteins. The mechanism of the possible influence of the L protein on cellular translation is unknown. There are hypotheses about the mechanism of...
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