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Article

Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.

28 May 1996

Abstract excerpt

Infection of cells with picornaviruses, such as poliovirus and encephalomyocarditis virus (EMCV), causes a shutoff of host protein synthesis. The molecular mechanism of the shutoff has been partly elucidated for poliovirus but not for EMCV. Translation initiation in eukaryotes is facilitated by the mRNA 5' cap structure to which the multisubunit translation initiation factor eIF4F binds to promote ribosome...

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PMID: 8643618
DOI: 10.1073/pnas.93.11.5578

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