Article
A translation system reconstituted with human factors proves that processing of encephalomyocarditis virus proteins 2A and 2B occurs in the elongation phase of translation without eukaryotic release factors.
The Journal of biological chemistry - 14 Nov 2014
Machida Kodai, Mikami Satoshi, Masutani Mamiko, Mishima Kurumi, Kobayashi Tominari, Imataka Hiroaki
Abstract excerpt
The genomic RNA of encephalomyocarditis virus (EMCV) encodes a single polyprotein, and the primary scission of the polyprotein occurs between nonstructural proteins 2A and 2B by an unknown mechanism. To gain insight into the mechanism of 2A-2B processing, we first translated the 2A-2B region in v...
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