Article
Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank.
Progress in neuro-psychopharmacology & biological psychiatry - 2 Mar 2024
Pan Chuyu, Cheng Shiqiang, Liu Li, Chen Yujing, Meng Peilin, Yang Xuena, Li Chun'e, Zhang Jingxi, Zhang Zhen, Zhang Huijie, Cheng Bolun, Wen Yan, Jia Yumeng, Zhang Feng
Abstract excerpt
BACKGROUND: Rare variants are believed to play a substantial role in the genetic architecture of mental disorders, particularly in coding regions. However, limited evidence supports the impact of rare variants on anxiety. METHODS: Using whole-exome sequencing data from 200,643 participants in the UK Biobank, we investigated the contribution of rare variants to anxiety. Firstly, we computed genetic risk score...
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